Gavin Henson will make his first Test start for more than a year when Wales tackle world champions South Africa at the Millennium Stadium this weekend.
The Ospreys star has been recalled by caretaker coach Nigel Davies. Henson's last full Wales appearance was against Australia in November last year.
Davies has opted for an all-Ospreys midfield on Saturday, with Henson partnering Sonny Parker in the centre and James Hook featuring at fly-half.
It means that Cardiff Blues and World Cup centre Tom Shanklin moves to the wing, while Llanelli Scarlets' fly-half Stephen Jones has to content himself with a place on the bench.
Scarlets' full-back, 23-year-old Morgan Stoddart, will make his Wales debut - after injury ruled out Ospreys' Lee Byrne.
Cardiff Blues prop Gethin Jenkins will captain Wales, while his fellow prop - South Africa-born Rhys Thomas - is rewarded for some impressive form in Newport Gwent Dragons colours.
The back-row vacancy created by flanker Martyn Williams' post-World Cup retirement from international rugby is filled by his Cardiff colleague Robin Sowden-Taylor.
Davies said: "Gavin's partnership with both James Hook and Sonny Parker at the Ospreys has been going well of late, which is the main reason for going with that combination.
"We have had our hand forced a little in the backs with injuries to both Lee Byrne and Jamie Robinson ruling them out of contention, but the result is a pretty exciting new-look back line which I am sure can make South Africa stand up and take notice.
"Morgan has been in a rich vein of form of late, and if he can retain his composure in what will be a cauldron atmosphere at the Millennium Stadium and allow his talent to shine through, then he could make quite a debut."
Wales to play South Africa at the Millennium Stadium on Saturday: M Stoddart (Llanelli Scarlets); M Jones (Llanelli Scarlets), S Parker (Ospreys), G Henson (Ospreys), T Shanklin (Cardiff Blues); J Hook (Ospreys), D Peel (Llanelli Scarlets); G Jenkins (Cardiff Blues, captain), H Bennett (Ospreys), R Thomas (Newport Gwent Dragons), A-W Jones (Ospreys), I Evans (Ospreys), C Charvis (Newport Gwent Dragons), R Sowden-Taylor (Cardiff Blues), J Thomas (Ospreys).
Replacements: TR Thomas (Cardiff Blues), D Jones (Ospreys), L Charteris (Newport Gwent Dragons), A Popham (Llanelli Scarlets), M Phillips (Ospreys), S Jones (Llanelli Scarlets), T James (Cardiff Blues).
Conor O'Shea will lead his side to matches against Fiji and Australia
30 March 2017, 2:36pm
After a disappointing RBS 6 Nations campaign for the Azzurri - losing all five of their Championship matches and picking up their 12th Wooden Spoon - they will be licking their wounds ahead of their summer tour Down Under.
The 2017 RBS 6 Nations was watched by record numbers of fans
29 March 2017, 12:25pm
After an enthralling RBS 6 Nations Championship of twists, turns, and no small amount of drama on the last day, figures show the RBS 6 Nations is going from strength to strength, year on year, with no sign of slowing down.