Irish provinces Leinster and Munster have joined the English clubs in making their players unavailable to play for the Barbarians against World Cup winners South Africa.
The Springboks conclude a short tour with a clash against the Baa-Baas on December 1 but the clubs are unwilling to release players due to other commitments.
The decision means Ireland centre Brian O'Driscoll will not captain the invitational side as had been planned.
A joint statement from the provinces read: "Contrary to media reports, neither Brian O'Driscoll nor Paul O'Connell nor any of the selected squads from the Leinster or Munster panels will be available for the upcoming Barbarians match against South Africa."
England flanker James Haskell insists he will be pushing as hard as possible to be back from a toe injury in time to make his case for a spot in Eddie Jones' side looking to defend their RBS 6 Nations title next year.