England centre Jamie Noon will begin his comeback from a World Cup-ending injury in Spain on Saturday.
Noon lines up in Newcastle's European Challenge Cup opener against Cetransa El Salvador, almost two months after suffering medial knee ligament damage during England's record 36-0 World Cup defeat to South Africa.
Noon is partnered in midfield by World Cup star Mathew Tait, with Tait and his brother Alex - chosen at full-back instead of Tom May - starting together in Falcons colours for the first time.
England pair Toby Flood and Jonny Wilkinson both miss the game.
Flood has undergone surgery to repair a minor tear in his scrotum suffered against EDF Energy Cup opponents Newport Gwent Dragons last weekend, while Wilkinson continues his recovery from an ankle problem.
England's preparations for the Autumn International series were potentially dealt a further blow as Maro Itoje was forced to undergo an x-ray after Saracens' European victory over Scarlets on Saturday night.