The RBS 6 Nations committee confirmed they have received a letter from the Argentina Rugby Union requesting a place in an expanded tournament.
The Pumas are anxious to build on their third-place finish at the World Cup by gaining entry into one of the established annual competitions.
The Tri-Nations is a possible home but, with almost the entire national squad playing their rugby in Europe, the Six Nations remains Argentina's preferred option.
An RBS 6 Nations spokesman said: "The Six Nations have received a letter from the Argentinian Union. We will acknowledge receipt of that letter to the Argentinians."
Hugo Porta, the former Pumas fly-half and advisor to the Union Argentina de Rugby, will present the Pumas' case for inclusion to the International Rugby Board later this month.
Porta said: "We will present our strategic plan to the IRB, which we have been working on at the UAR for a long time with the purpose of getting Argentina included in future international competitions.
"So many of the current players consider it more viable to play in the Six Nations in Europe because it's there that most of the Argentinian players play."
Wales' acting head coach Rob Howley has given Sam Davies and Rory Thornton a boost ahead of the RBS 6 Nations by naming the uncapped Ospreys duo in his largely experienced squad for the Autumn Internationals.