The other fresh face comes in the back row with Northampton Saints' Phil Dowson pipping Scarlets rookie Ben Morgan to the No. 8 jersey.
Charlie Hodgson and David Strettle return for their first starts since a clash with New Zealand back in 2008 while Mouriz Botha and Chris Robshaw, at skipper, will win just their second caps.
On the bench comes a flood of fresh faces with Rob Webber, Geoff Parling, Morgan, Lee Dickson and Jordan Turner-Hall all set to win their first caps.
And Lancaster believes he's got the right blend to emerge from Murrayfield victorious.
"We have been impressed with how the whole group has come together in the last ten days and we have done a lot of work on and off the field," said Lancaster.
"Now is the time to turn all that into a performance against Scotland that we can all be proud of. It is a massive challenge - Murrayfield, the first game of the Six Nations - but one we are relishing."
15 Ben Foden (Northampton Saints)
14 Chris Ashton (Northampton Saints)
13 Brad Barritt (Saracens)
12 Owen Farrell (Saracens)
11 David Strettle (Saracens)
10 Charlie Hodgson (Saracens)
9 Ben Youngs (Leicester Tigers)
1 Alex Corbisiero (London Irish)
2 Dylan Hartley (Northampton Saints)
3 Dan Cole (Leicester Tigers)
4 Mouritz Botha (Saracens)
5 Tom Palmer (Stade Francais)
6 Tom Croft (Leicester Tigers)
7 Chris Robshaw (Harlequins)
8 Phil Dowson (Northampton Saints)
16 Rob Webber (London Wasps)
17 Matt Stevens (Saracens)
18 Geoff Parling (Leicester Tigers)
19 Ben Morgan (Scarlets)
20 Lee Dickson (Northampton Saints)
21 Jordan Turner-Hall (Harlequins)
22 Mike Brown (Harlequins)