Both sides boast 100% records with two wins from their opening two matches, but it is Wales who are favourites as they bid for their 20th Championship Triple Crown having seen off Ireland and Scotland in impressive style.
Despite their strong start the Wales head coach is adamant his players keep their focus especially as they have managed a single win in 25 years at Twickenham, albeit under his tenure in the Grand Slam season of 2008.
"There is only one consequence of being built up and that is you get quickly knocked down," said Gatland. "We have got to make sure we keep our feet on the ground.
"A lot of people are talking us up which is going to add to England's motivation, and we have got to handle that.
"It is a great challenge for us going to Twickenham as favourites. This young team has got to learn to accept that and deal with those expectations, because in Wales there is nothing in between - it is all or nothing."
Wales welcome lock Alun Wyn Jones and hooker Richard Hibbard back into their squad while Sam Warburton is expected to return to training and captain the side against England after a late withdrawal before the Scotland match.
And with Stuart Lancaster's side struggling to convince during their two victories in Edinburgh and Rome, Gatland feels there has never been a better time to travel to the home of English rugby.
"There is definitely not that fear factor now. We are not afraid of going to Twickenham, we are excited about it.
"I have generally got fond memories of Twickenham but talking to some Wales players who played over the past 20 years, it was a bit different when they were fully loaded with [Martin] Johnson, [Lawrence] Dallaglio, [Neil] Back and all the others.
"I expect England might have the attitude that if they can get four penalties, a try and conversion and get 19 points, and they can squeeze us, that might be enough.
"If we go there with our heads right and get some quality ball, we have got a good chance."