But Halfpenny says Wales won't be satisfied with conquering Stuart Lancaster' side unless they go on to defeat Italy and France at the Millennium Stadium on March 10 and 17 to record their second clean sweep in four years.
"At the end of the day we want to be the best," said Halfpenny. "That means winning every single game and achieving the Grand Slam. That is the objective in this tournament - nothing less.
"We are preparing for this tournament as we did the World Cup, which was another tournament we set out to win. We want to be the best, and we set high goals to bring the best out of us.
"We train as hard as possible, and nothing less than our best will do. Everyone is ambitious, from the coaches to the players. Winning trophies is our goal, and we believe we can achieve that."
It is not often Wales go to Twickenham as clear favourites, and the 23-year-old attributes the World Cup semi-finalists' Six Nations success to the rigorous training camp they endured in Poland last month.
"We were pushed to the limits of our endurance - and beyond - out there. Your mind is drained, and you need the support of your team-mates to lift you and pull you through, making sure we all get to the finishing line.
"There were times when you felt like giving up. You thought you had no more to offer and then, from somewhere, you find an extra bit."