Clive Woodward has vowed to take no notice of the RBS 6 Nations form guide which suggests tournament favourites England will give Wales a Millennium Stadium mauling on Saturday.
England, who have not lost in Cardiff since 1993, head for the Welsh capital later this week with 11 survivors in their starting line-up from last season's record 50-10 victory at Twickenham.
Wales are still feeling the after-effects from a 30-22 defeat by Italy, and Wales coach Steve Hansen's team selection - scheduled for Thursday - is likely to show several changes, including the possibility of him naming a new captain.
Woodward, though, is taking nothing for granted as England look to complete the second stage of a possible 6 Nations Grand Slam.
"In any of these 6 Nations games, and I speak from a lot of experience here, if you get anything wrong, then you will lose," he said.
"I am sure that Wales will think they have got a lot to prove, having lost their first game. If you lose your first game in the 6 Nations, then the second is a must-win.
"We are under no illusions that it is going to be a tough game on Saturday. There will be no problem with our guys in terms of focusing on the game.
"We've got a lot of experience about losing games in the championship that we should have won."
England Under-20s suffered a first-ever defeat to their Scottish counterparts on Friday night and head coach Jon Callard admits his young charges will need to put that out of their minds as soon as possible if they harbour hopes of retaining the Under-20s Six Nations title.