Ireland internationals Denis Leamy and Tony Buckley both scored and kiwi Doug Howlett added another in the first-half to open up a 21-10 lead at the interval.
Mick O'Driscoll, James Coughlan and Howlett crossed again after the break to seal a comprehensive victory.
Jean-Phillipe Genevois and Joe van Kiekerk responded with tries for Toulon but it wasn't enough.
Allan Jacobsen, Netani Talei and Ben Cairns all bagged tries for Edinburgh - but it wasn't enough to give them victory over Northampton as they slipped to a 31-27 defeat.
Tries by Dylan Hartley and James Downey kept the visitors in touch at the interval while Paul Diggin's touchdown and Stephen Myler's accurate kicking ensured victory for Saints.
Will Harries' try and 14 points from the boot of fly-half Matthew Jones were all Newport Gwent Dragons could muster as they were downed 42-19 at home to Toulouse.
And Leinster edged their encounter with Saracens 25-23 with Jonny Sexton kicking ever point for the Irish side.