Fellow Welsh international Alun Wyn Jones will lead the side for the 2010/11 season but his international skipper is expected to be alongside him for the clash with Aironi at the Liberty Stadium.
Ospreys forwards coach Jonathan Humphreys said: "Hopefully he'll be available for selection this week.
"It's a significant boost to us to have him back, because we've always felt he's such a big player for the Ospreys.
"We rate his efforts very highly here - he's one of our hardest-working players on the field.
"He's a leader, so it'll be great to have him back in the ranks."
And the Ospreys have been given more good news this week with Wales second row Ian Evans looking set for an ahead-of-schedule return from injury.
Evans - who has 16 international caps - limped off in the 22-10 defeat against Munster but is expected to be fit for a return for the Toulon clash on October 9.