Glasgow make two changes to last week's side with Ed Kalman replacing Moray Low at tighthead and debutant Chauncey O'Toole coming in for Ryan Wilson at blindside.
And Lineen has emphasised the importance of winning on the road, after notching four wins, three losses and two draws away in the previous campaign.
"This is a huge game," said Lineen. "We had a good away record last season of four wins and two draws, but we're travelling down to Newport and it's going to be difficult.
"All six home teams won last weekend so it's going to form in terms of home advantage but it's going to crack at some point and it would be great for us to do it against Newport on Sunday.
"Newport are going to be tough but it's a good one to get after the high against Leinster."