Sale director of rugby Kingsley Jones admitted Andrew Sheridan could miss England's autumn internationals after he dislocated his left shoulder in last night's 27-26 Heineken Cup victory over Pool Five rivals Cardiff.
The British and Irish Lions prop sustained the injury in the 73rd minute following a scrum and could be out for around three months, ruling him out of England's Test matches next month.
Jones said: "It looks like Andrew has dislocated his shoulder.
"It has gone out and come back in again, and if he misses the autumn internationals it would be a big loss because we know how important he is to England."
Sheridan's injury marred a classic encounter which saw Sale's teenage lock James Gaskell enhance his fast-growing reputation with a virtuoso performance.
The 19-year-old lock from Sandbach, who stands 6ft 7in, created a try for skipper Dean Schofield in the 37th minute with a fine run and then went over himself shortly after the restart as Sale responded in style to last week's thumping defeat in Toulouse.
Wales' acting head coach Rob Howley has given Sam Davies and Rory Thornton a boost ahead of the RBS 6 Nations by naming the uncapped Ospreys duo in his largely experienced squad for the Autumn Internationals.