Danny Cipriani has lost his place in England's 32-man elite player squad to Jonny Wilkinson.
Cipriani started last season as England's first choice fly-half yet finished it as a substitute for the Saxons at the Churchill Cup.
The 21-year-old Wasps back must settle for a place in the Saxons squad after making way for World Cup winner Wilkinson, who has returned to full fitness.
Wilkinson, who has signed for Toulon, is one of only two French-based players included in either squad with Brive's Riki Flutey the second.
James Haskell, Andy Goode and Jamie Noon are among those who have joined French clubs that have been omitted.
England manager Martin Johnson said: "Our selections include players based in France and Rob Andrew and I have had extensive discussions with the French clubs, who have recruited English players and these have gone well.
"We are looking forward to continuing the positive working relationship with them, which worked so well last season.
"We will continue to monitor the form and fitness of the following players who were involved with England last season with a view to inviting them to training sessions as appropriate - Andy Goode, James Haskell, Tom May, Jamie Noon, Tom Palmer and Steve Thompson."
Goode was heavily involved with England last season, winning seven caps, despite not being included in either squad while Thompson featured on the tour to Argentina.
Bath prop David Wilson impressed Johnson during the summer fixtures against the Barbarians and Argentina and has been rewarded with a place in the EPS.
But the star of the summer was Wilson's club colleague Matt Banahan who shone in all three matches after being promoted from the Saxons as injury cover for David Strettle.
Strettle remains among the Saxons where he is joined by utility back Ben Foden and winger Paul Sackey.
Leicester quartet Louis Deacon, Jordan Crane, Ben Kay and Dan Hipkiss are promoted to the EPS following their participation on this summer's tour to Argentina.
Nicky Kennedy, the London Irish lock, and Leicester openside Lewis Moody head in the opposite direction into a Saxons squad that also includes Northampton's 20-year-old wrecking ball Courtney Lawes.
England's preparations for the Autumn International series were potentially dealt a further blow as Maro Itoje was forced to undergo an x-ray after Saracens' European victory over Scarlets on Saturday night.