Wales wing Mark Jones and scrum-half Gareth Cooper have been declared fit to face the USA at Toyota Park on Saturday.
Jones missed last Saturday's Test against Canada in Toronto with a knee injury but the Scarlets wing is back in contention for a starting place when caretaker coach Robin McBryde names his team to play the Eagles tomorrow.
"I don't envisage there being too many changes," Wales assistant coach Sean Holley said.
"There are a couple of injuries that are going to come into the reckoning but Mark Jones is back in full training and that's good news for us, and most of the others apart from Brad Davies have come through pretty unscathed."
Cardiff Blues lock Davies will play no further part in the tour of North America having chipped a bone in his neck late in the game against Canada, and Dragons second row Luke Charteris has already arrived in Chicago as his replacement.
Cooper also hobbled out of last weekend's 32-23 victory over the Canadians, making way for Dwayne Peel at half-time, but the Cardiff Blues-bound scrum-half is also back in training and fit to face the Americans, according to Holley.
"He's fine, he was taken off as a bit of a precaution, when you've got somebody like Dwayne on the bench as well," he said.
"He took a bit of a knock but he was cleared after the game and has taken a full part in training since then."
Asked if there would be many changes to the Wales side from the one that beat Canada, Holley said: "I don't think so.
"Robin has made it pretty clear that you have to earn the right to play for Wales and there were a lot of good performances there at the weekend."
The RBS 6 Nations Championship 2015 was not poised to go down as one of the more "vintage" Championships, though there was great anticipation as the action headed into its final day. What transpired was something that nobody could foresee: "The Greatest Day in Rugby's Greatest Championship."