Cast your mind back 12 months and it was such a different story, the 30-3 mauling of the Red Rose that sealed the 2013 Championship proved to be one of Gatland's finest hours.
The New Zealander certainly isn't messing around this time - the man so used to the big-game occasion has left out two of his trusted front-row lieutenants in Adam Jones and Richard Hibbard in favour of Rhodri Jones and Ken Owens.
The guards appear to be changing with Jones, a cornerstone of three previous Grand Slam successes, normally a shoo-in for the number three jersey whenever fit.
By the time the World Cup swings by in 18 months time, though, Jones will be 34 and this dead-rubber against the Scots - who have beaten Italy and lost their other three fixtures - appears to perfect opportunity to blood youngsters.
But Gatland will never let up on a chance to put things right and he's still irked by the loss to England.
"Saturday is an opportunity for us to put in a performance we know we can and finish the Six Nations on a high," he said.
"We've made a number of changes and freshened things up with a just a six-day turnaround between matches.
"Scotland will come looking to play some rugby and had a morale boosting win against Italy and were unlucky to lose against France in recent weeks."
Continuing the theme of change is a new half-back pairing in Dan Biggar and Mike Phillips, replacing Rhys Priestland and the injured Rhys Webb respectively.
The 22-year-old Liam Williams is also given the nod to step into the full-back slot vacated by Leigh Halfpenny - whose shoulder injury looks set to rule him out for the remainder of the season.
While 31-year-old lock Luke Charteris takes the place of Jake Ball in the third and final change to the pack.
"Liam (Williams) and Mike (Phillips) come in with Leigh (Halfpenny) and Rhys (Webb) ruled out and Dan Biggar gets his opportunity at fly-half," added Gatland.
"In the front-row Ken Owens and Rhodri Jones get their chance to start after impressing off the bench and it's good to have Luke (Charteris) back from injury in the second-row."
Scotland, too, are bracing themselves for a re-jig with coach Scott Johnson taking charge of his final game before becoming Scottish Rugby Union's director of rugby.
Johnson has been keeping the seat warm for Vern Cotter and, having won five of his 15 games in charge, the Australian will be looking to mark it in style in Cardiff.
But he insists his side must not be distracted from the task in hand on Saturday.
"It's not about me. I did it for what I feel is the right fit for Scotland and I'll take up a different role and I'll enjoy that - but I'm really proud to say I've been a part of it," he said.
Johnson has had plenty to consider ahead of his last game in charge with injuries seeing him delay his initial team announcement.
Edinburgh winger Dougie Fife has been handed a debut following injuries to Sean Lamont and Tommy Seymour, with Max Evans starting on the other wing.
Evans will win his 42nd cap for Scotland in Cardiff with Jack Cuthbert providing back three cover on the bench.
And while Fife gets his chance as a replacement for Seymour, who has not recovered from an ankle injury sustained against France, Johnson believes he can stamp his mark on the occasion.
"We like Dougie's size and his competitive edge. He chases everything, which I like, and he has shown really good glimpses playing for Edinburgh this season," said Johnson.
"He's been ear-marked by us for a while - we've been following him for the last 12 months - and he's got his reward now. If he gets this one right, you might find that he puts a bit of pressure on (for a place) going forward, which is really good.
"I don't really think Saturday will faze Dougie. He's one of those players where it doesn't seem to matter who he marks he just goes out and plays the same."