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It means that Brian O'Driscoll will equal the world record number of Test caps won, currently held by Australia scrum-half George Gregan, who won 139.
Schmidt has made two changes to the bench with Iain Henderson replacing Ulster teammate Dan Tuohy, who fractured his arm against Wales, while Jordi Murphy provides back row cover and will win his first cap should he come off the bench.
"I think we've got to get the little things right," said Schmidt.
"We've got to get the pressure on and the only way to do that is to be well-organised and combative."
Paul O'Connell leads the side looking for a first win at Twickenham since 2010 while O'Driscoll is seeking a ninth career win over England which would also be another national record.
He's partnered in midfield by Gordon D'Arcy and Ireland have never lost to England when he, O'Connell and O'Driscoll have been in the side together.
Mike Ross, Rory Best and Cian Healy continue in the front row while Devin Toner partners O'Connell in the engine room.
Peter O'Mahony, man of the match in the victory over Wales last time out, is again joined by Chris Henry and Jamie Heaslip in the back row.
Conor Murray and Jonathan Sexton are again the half-backs while Dave Kearney and Andrew Trimble continue on the wings and Rob Kearney stays at full-back.
IRELAND SIDE TO FACE ENGLAND
15. Rob Kearney (UCD/Leinster)
14. Andrew Trimble (Ballymena/Ulster)
13. Brian O'Driscoll (UCD/Leinster)
12. Gordon D'Arcy (Lansdowne/Leinster)
11. Dave Kearney (Lansdowne/Leinster)
10. Jonathan Sexton (Racing Metro 92)
9. Conor Murray (Garryowen/Munster)
1. Cian Healy (Clontarf/Leinster)
2. Rory Best (Banbridge/Ulster)
3. Mike Ross (Clontarf/Leinster)
4. Devin Toner (Lansdowne/Leinster)
5. Paul O'Connell (Young Munster/Munster)
6. Peter O'Mahony (Cork Constitution/Munster)
7. Chris Henry (Malone/Ulster)
8. Jamie Heaslip (Dublin University/Leinster)
16. Sean Cronin (St. Mary's College/Leinster)
17. Jack McGrath (St. Mary's College/Leinster)
18. Martin Moore (Lansdowne/Leinster)
19. Iain Henderson (Ballinahinch/Ulster)
20. Jordi Murphy (Lansdowne/Leinster
21. Isaac Boss (Terenure College/Leinster)
22. Paddy Jackson (Dungannon/Ulster)
23. Fergus McFadden (Old Belvedere/Leinster)