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But Saint-Andre, whose side narrowly beat Scotland in Edinburgh last Saturday to keep their title hopes alive, clearly feels Picamoles has served his time and has included him in his 30-man squad.
The 28-year-old's inclusion means that Antonie Claassen is left out while the Racing Metro pair of Bernard Le Roux and Dimitri Szarzewski both return from injury.
Not included however is Morgan Parra, the scrum-half is now available for selection after serving a ban for a headbutt while on club duty with Clermont, but Saint-Andre has opted to retain Maxime Machenaud and the match-winner in Edinburgh, Jean-Marc Doussain.
"After this narrow victory in Edinburgh, we have made two logical returns to the squad that has been together since the start of the tournament in order to be best prepared for next Saturday's clash with Ireland," said Saint-Andre.