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The Autumn internationals will also provide a useful marker ahead of the 2015 RBS 6 Nations with the Red Rose looking to go one better than the runner's up spot managed earlier this year.
And 25-year-old Twelvetrees, who will first turn his attention to club side Gloucester after being named captain last week, knows how important momentum will be if England want to be serious contenders.
"It's a massive year for England with the World Cup at home and also with Gloucester as one of the venues, which is good for the local game," he told the Gloucester Citizen.
"The three southern hemisphere teams are always the three toughest to beat, we've got them in the autumn, as well as Samoa, so it would be good to get four out of four going into the Six Nations to build the confidence ahead of the World Cup.
"But my focus is at Gloucester, playing well here for the boys and making this place a fortress again. We've all worked really hard and have a massive year ahead."
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