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As expected, Lancaster has called on Wilson to replace the injured Dan Cole at tighthead prop while 20-year-old fly-half George Ford features in the squad for the first time, having been named on the bench.
Wilson, 28, came off the bench against New Zealand in the autumn while he also started all three of England's victories over Argentina in 2013.
A calf injury had kept him out of England's two RBS 6 Nations matches however but he returned to action for Bath last weekend and in Cole's absence, he goes straight into the starting line-up.
Since making his debut in 2009 Wilson has amassed 31 caps but only seven of those have been from the start.
But Lancaster has every faith in Wilson, who is set for a key battle with Ireland loosehead Cian Healy.
"We are excited about being back at our home after two games on the road," said Lancaster. "The Twickenham crowd during the November internationals was superb and I'm sure it'll be the same again on Saturday.
"We have been forced into one change and we wish Dan Cole all the best for his recovery. However, David Wilson is an experienced international with 31 caps and he showed in his three starts against Argentina last year what he can do."
Ford comes onto the bench in place of Brad Barritt, ensuring England's backline remains the same with Danny Care and Owen Farrell at half-back while Billy Twelvetrees and Luther Burrell continue at centre.
"It's great to have George involved," added Lancaster. "He has settled in well and we are confident in his ability should he get his opportunity from the bench."
Wingers Jack Nowell and Jonny May win their first caps at Twickenham while Mike Brown stays at full-back.
Dylan Hartley and Joe Marler complete the front row with Joe Launchbury and Courtney Lawes continuing their burgeoning partnership in the second row. Tom Wood, skipper Chris Robshaw and Billy Vunipola make up the back row.
ENGLAND SIDE TO FACE IRELAND
15. Mike Brown (Harlequins)
14. Jack Nowell (Exeter Chiefs)
13. Luther Burrell (Northampton Saints)
12. Billy Twelvetrees (Gloucester)
11. Jonny May (Gloucester)
10. Owen Farrell (Saracens)
9. Danny Care (Harlequins)
1. Joe Marler (Harlequins)
2. Dylan Hartley (Northampton Saints)
3. David Wilson (Bath)
4. Joe Launchbury (London Wasps)
5. Courtney Lawes (Northampton Saints)
6. Tom Wood (Northampton Saints)
7. Chris Robshaw (Harlequins)
8. Billy Vunipola (Saracens)
16. Tom Youngs (Leicester Tigers)
17. Mako Vunipola (Saracens)
18. Henry Thomas (Sale Sharks)
19. Dave Attwood (Bath)
20. Ben Morgan (Gloucester)
21. Lee Dickson (Northampton Saints)
22. George Ford (Bath)
23. Alex Goode (Saracens)