Leicester were left counting the cost of England's RBS 6 Nations victory over Scotland on Saturday after three of their players suffered injuries.
Forwards Graham Rowntree, Ben Kay and Lewis Moody will all miss the Tigers Premiership clash with Leeds on Sunday.
Prop Rowntree withdrew from the Calcutta Cup clash at Twickenham before kick-off with a hip problem, while second row Kay left the field after just 14 minutes with a sprained ankle.
Flanker Moody limped off at half-time with sprained groin and stomach muscles.
Tigers head coach John Wells said: Graham's definitely out of this weekend's game, but we won't know the full extent of Ben's injury until later in the week.
Lewis seems the most serious of the lot, yet he doesn't think it's too bad.
Wells will hope to have the trio back in contention for next weeks European Cup quarter-final against Leinster in Dublin.
Backs Harry Ellis (neck) and Ollie Smith (shoulder) also returned to Leicester with knocks but should be fit for the weekend.