Italy recovered from their thrashing at the hands of New Zealand a fortnight ago with a well-earned 43-25 win at the expense of the United States at Biella's Stadio La Marmora.
It only took Italy seven minutes to get in front with Luciano Orquera and Andrea Lo Cicero creating the opening for Kaine Robertson who touched down.
Ten minutes later fly-half Orquera added a penalty and shortly afterwards Robertson touched down again with a breakaway try.
The Americans lost possession on the Italian 22 metre line and Paul Griffen launched a counter-attack with Walter Pozzebon.
Pozzebon fed Cristian Stoica who sprinted clear and offloaded to the supporting Robertson to take the score to 13-0.
Another Orquera penalty increased the margin to 16-0 and two minutes later Pozzebon scored Italys third try, a fine solo effort. Orquera added the extra points to give the Azzurri a 23-0 lead.
Italy were rampant and then Griffen and Orquera created a try for Stoica to cap a memorable week for the Romania-born centre who became the father of a son, Matteo, a week ago.
Just before the interval, the USA got on the board with a penalty from Mike Hercus and at the interval the hosts still had a healthy 30-3 lead.
Five minutes into the second period Paul Emerick broke through a Fabio Ongaro tackle to score the visitors first try.
Then Orquera scored a brilliant solo interception try to touch down under the posts and the resulting conversion took the score to 40-8.
Italy relaxed and then the Americans began to create more and replacement Albert Tuipulotu scored after a half-hearted tackle from Stoica with Hercus adding the extra points.
Given the absentees and the fact that most American points came when the game was already won it was a second convincing win for Italy over North American opposition
after they thrashed Canada 51-6 at LAquila in their first November Test.
Italy: Roland De Marigny; Kaine Robertson, Walter Pozzebon, Cristian Stoica, Ludovico Nitoglia; Luciano Orquera, Paul Griffen; Andrea Lo Cicero, Fabio Ongaro, Salvatore Perugini, Cristian Bezzi, Valerio Bernabo, Enrico Ravanello, Silvio Orlando, David Dal Maso.
Replacements: Giorgio Intoppa, Salvatore Costanzo, Roberto Mandelli, Antonio Mannato, Pietro Travagli, Andrea Scannavacca, Matteo Barbini.
USA: Francois Viljoen; Al Lakomskis, Paul Emerik, Salesi Sika, David Fee; Mike Herchus, Mose Timoteo; Mike Macdonald, Matt Wyatt, Jacob Waasardop, Alec Parker, Gerhard Klerck, Jurie Gouws, Brian Surgener, Kort Schubert.
Replacements: Mike Hobson, Chris Osentowsky, Matt Kane, Fifita Mo'unga, David Williams, Matt Sherman.