Brian O'Driscoll will win his 51st cap and his 14th as captain in the first Test against South Africa at Bloemfontein.
Ireland's record try-scorer will lead out an unchanged team from that which defeated Scotland to win the Triple Crown in March.
A 65th cap for second row Malcolm O'Kelly brings him to within four of the Irish record haul of 69, established by Mike Gibson from 1964-79.
Other cap milestones in Bloemfontein will see prop John Hayes reach the 45-mark, blindside flanker Simon Easterby win his 33rd cap, hooker Shane Byrne and winger Shane Horgan claim their 30th caps and second row Paul O'Connell and openside flanker David Wallace make their 20th appearances.
Alan Quinlan's selection in the replacements marks his first time in the 22 since injuring a shoulder while scoring a try against Argentina in the World Cup in Australia in October 2003.
Ireland: G Dempsey (Leinster, Terenure College); S Horgan (Leinster, Lansdowne), G Darcy (Leinster, Lansdowne), B O'Driscoll (Leinster, Blackrock College, capt), G Murphy (Leicester); R O'Gara (Munster, Cork Constitution), P Stringer (Munster, Shannon); R Corrigan (Leinster, Greystones); S Byrne (Leinster, Blackrock College), J Hayes (Munster, Shannon), M O'Kelly (Leinster, St Mary's College), P O'Connell (Munster, Young Munster), S Easterby (Llanelli), D Wallace (Munster, Garryowen), A Foley (Munster, Shannon).
Replacements: F Sheahan (Munster, Cork Constitution), M Horan (Munster, Shannon), Donncha O'Callaghan (Munster, Cork Constitution), Alan Quinlan (Munster, Shannon), G Easterby (Rotherham), David Humphreys (Ulster, Dungannon), K Maggs (Bath).