Iestyn Harris has urged Wales to prey on a wounded England team and cause another Celtic calamity for the world champions.
England face a true Twickenham character test after being rolled over by Ireland last time out.
And while the reigning RBS 6 Nations champions are confidently expected to get their campaign back on track, Wales have no intention of playing second-fiddle.
The start is imperative for us - weve got to get a good start, said former rugby league star Harris, who lines up in the Welsh midfield for his 25th cap.
England lost their last game, and they will have a few little worries in the back of their mind. The worse thing we can do is give them an easy start.
Weve really got to take it to them, and try and get some points on the scoreboard early, and hopefully they will start to worry a little bit.
England are going to be wounded. They are saying that they are going to turn things around and show the crowd and everyone else what a top-class side they are.
Thats all well and good, but if we get a good start, then they will start questioning themselves.
Harris has no doubt that the absence of retired World Cup leader Martin Johnson left a huge void when England crashed to their first home defeat against Ireland for ten years.
Martin Johnson has been in the England pack for a long time, the sort of glue that has held them together for so long, he added.
Whenever theyve had a dodgy five or 10 minutes in a game, hes been there to pull them together. I think they missed him for the first time against Ireland.
Hopefully, we can put the same kind of pressure on them. They are going to be worried with how it went against Ireland, theyve not got Johnson, and there is no reason why we cant put questions in their mind.