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Samoa are also unbeaten, having seen off Grand Slam champions Wales in Cardiff last time out, and Saint-André has chosen to make three changes to his starting lineup for the clash.
Morgan Parra will start at scrum-half in place of Maxime Machenaud while Clermont pair Benjamin Kayser and Thomas Domingo come into the front row for Yannick Forestier and Dimitri Szarzewski.
Saint-André said: “We were the outsiders against Australia, it was 50-50 against Argentina and now we are in the role of favourites.
"We will see if we are capable of assuming that mantle and once again winning. We are trying to instil a culture of quality and consistency at the topmost level. That is the challenge that awaits us on Saturday."
France team to play Samoa
15. Brice Dulin – Castres
14. Wesley Fofana – Clermont
13. Florian Fritz – Toulouse
12. Maxime Mermoz – Toulon
11. Vincent Clerc – Toulouse
10. Frederic Michalak – Toulon
9. Morgan Parra – Clermont
1. Thomas Domingo – Clermont
2. Benjamin Kayser – Clermont
3. Nicolas Mas – Perpignan
4. Pascal Pape – Stade Francais
5. Yoann Maestri – Toulouse
6. Yannick Nyanga – Toulouse
7. Fulgence Ouedraogo – Montpellier
8. Louis Picamoles - Toulouse
16. Dimitri Szarzewski – Racing
17. Yannick Forestier – Castres
18. Vincent Debaty – Clermont
19. Jocelino Suta – Toulon
20. Damien Chouly – Clermont
21. Maxime Machenaud – Racing
22. Francois Trinh-Duc – Montpellier
23. Yoann Huget – Toulouse