The Official Online RBS 6 Nations Store is open. The store has everything you need to get behind your team during the RBS 6 Nations, plus the store is now fully stocked with a much wider range of rugby merchandise.
Wasps lock Launchbury has been preferred to Mouritz Botha and George Robson while Saracens prop Vunipola gets the nod ahead of Alex Corbisiero who is still returning from a knee injury.
Elsewhere, Charlie Sharples looks likely to start on the right wing in the absence of the suspended Chris Ashton with Ugo Monye returning for his first cap since the 2010 RBS 6 Nations.
Chris Robshaw will again skipper the side and looks set to start in the back row alongside No.8 Thomas Waldrom and flanker Tom Johnson.
Up front Joe Marler appears to have shaken off a knee injury to take his place at loosehead prop with Tom Youngs expected to win his first cap at hooker and Dan Cole at tighthead.
And head coach Lancaster could not hide his excitement, particularly for his two young guns, ahead of the Fiji clash.
"Saturday is a great opportunity for us to put a marker down and deliver a quality performance," he said.
"It's great to have young players such as Mako and Joe get their opportunities in the matchday 23 and we are excited about the potential of the squad."
The ten players released by England back to their clubs are Gloucester trio Ben Morgan, Freddie Burns and Billy Twelvetrees, Leicester’s Anthony Allen, Saracens’ Botha, Northampton pair Lee Dickson and Phil Dowson, Harlequins’ Robson, Wasps’ James Haskell and London Irish’s Corbisiero.