Youngs, who scored the final try in this year’s RBS 6 Nations against Ireland, touché down twice to inspire a spirited England second-half fightback in a 36-27 second Test defeat to the Springboks in Johannesburg on Saturday.

The 22-year-old was substituted after 74 minutes and showed no indication of suffering from any pain, but Lancaster has confirmed he will miss the rest of the tour because of a shoulder injury.

Harlequins' Karl Dickson has been recalled into the squad as his replacement, while Youngs’ withdrawal means Lee Dickson or Danny Care could start Saturday’s third and final Test in Port Elizabeth.

Lancaster said: “He has picked up a shoulder injury. He didn't present it until the end of the game obviously but it was only when we got back and he was struggling to move it – he is out of the tour.

“From our point of view he was excellent for us in the second Test, he really played well and he is devastated.

“But opportunities present themselves for other players – Lee Dickson and Danny Care. It won't be any disruption. Both Danny and Lee know the game plans, and we have got Lee's brother Karl winging in from Alicante.

“Karl was somewhere in Spain but we have managed to get him to Heathrow and he is on his way now.”