Saracens Brad Barritt and Owen Farrell will form a new centre pairing at international level, while Northampton Saints’ Phil Dowson makes his debut at No 8.
The match 22 sees five more uncapped players on the replacements’ bench – Rob Webber (London Wasps), Geoff Parling (Leicester Tigers), Ben Morgan (Scarlets), Lee Dickson (Northampton Saints) and Jordan Turner-Hall (Harlequins).
Head Coach Stuart Lancaster said: “We have been impressed with how the whole group has come together in the last 10 days and we have done a lot of work on and off the field.
“Now is the time to turn all that into a performance against Scotland that we can all be proud of. It is a massive challenge – Murrayfield, the first game of the Six Nations – but one we are relishing.”
England
15 Ben Foden (Northampton Saints)
14 Chris Ashton (Northampton Saints)
13 Brad Barritt (Saracens)*
12 Owen Farrell (Saracens)*
11 David Strettle (Saracens)
10 Charlie Hodgson (Saracens)
9 Ben Youngs (Leicester Tigers)
1 Alex Corbisiero (London Irish)
2 Dylan Hartley (Northampton Saints)
3 Dan Cole (Leicester Tigers)
4 Mouritz Botha (Saracens)
5 Tom Palmer (Stade Francais)
6 Tom Croft (Leicester Tigers)
7 Chris Robshaw (Harlequins, capt)
8 Phil Dowson (Northampton Saints)*
Replacements
16 Rob Webber (London Wasps)*
17 Matt Stevens (Saracens)
18 Geoff Parling (Leicester Tigers)*
19 Ben Morgan (Scarlets)*
20 Lee Dickson (Northampton Saints)*
21 Jordan Turner-Hall (Harlequins)*
22 Mike Brown (Harlequins)
*Uncapped
Charlie Sharples (Gloucester Rugby) and Joe Marler (Harlequins) will travel as reserves
Click here to see Stuart Lancaster's first interview on team selection, exclusive to RFU.tv
Dave Barton
Senior England Teams Media Manager
+44 (0)7736 517610
+44 (0) 208 831 7630
davebarton@rfu.com
@Official_RFU