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He replaces club teammate Mitchell who suffered a dislocated shoulder against Ireland having impressed in Wales’ three opening Six Nations matches.
Meanwhile North has the tough task of filling the boots of Williams after Wales’ record try scorer was ruled out with a knee injury.
The Scarlets youngster made a big impact when he made his international bow aged just 18, scoring twice against world champions South Africa , but has been out of action for three months.
“It goes without saying that we will miss Shane, any side would, but George presents an entirely different prospect,” said kicking coach Neil Jenkins.
“We are putting no pressure on him, he will just be told to go out there and enjoy his rugby.
“Adam is quite a player to have coming back into your side, he is a British Lion and one of the best players in his position in the world so we are very happy that he has timed his return from injury to perfection.
“Craig has done a great job for us so far this campaign, but it is reassuring to know Adam is there to slot straight back in. We know now that when everyone is fit we will have real depth in that front-row."
15 – Lee Byrne (Ospreys)
14 – Leigh Halfpenny (Blues)
13 – Jamie Roberts (Blues)
12 – Jonathan Davies (Scarlets)
11 – George North (Scarlets)
10 – James Hook (Ospreys)
9 – Mike Phillips (Ospreys)
1 – Paul James (Ospreys)
2 – Matthew Rees (Scarlets) (captain)
3 – Adam Jones (Ospreys)
4 – Bradley Davies (Blues)
5 – Alun Wyn Jones (Ospreys)
6 – Dan Lydiate (Dragons)
7 – Sam Warburton (Blues)
8 – Ryan Jones (Ospreys)
16 – Richard Hibbard (Ospreys)
17 – John Yapp (Blues)
18 – Jonathan Thomas (Ospreys)
19 – Rob McCusker (Scarlets)
20 – Dwayne Peel (Sale Sharks)
21 – Stephen Jones (Scarlets)
22 – Morgan Stoddart (Scarlets)