The Official Online RBS 6 Nations Store is open. The store has everything you need to get behind your team during the RBS 6 Nations, plus the store is now fully stocked with a much wider range of rugby merchandise.
Brive fly-half Orquera, making his first six nations start in six years, comes in for Kris Burton while Pablo Canavosio will be his half back partner replacing the injured Edoardo Gori.
Meanwhile up front Carlo Del Fava replaces Santiago Dellape in the second row and Valerio Bernabo earns a first Six Nations start in place of the injured Josh Sole.
Italy have not beaten England in any of their 16 previous encounters but pushed Martin Johnson's side all the way last year in Rome in a 17-12 defeat.
15 - Luke McLean (Benneton Treviso)
14 - Andrea Masi (Racing Metro)
13 - Gonzalo Canale (Clermont)
12 - Alberto Sgarbi (Benneton Treviso)
11 - Mirco Bergamasco (Racing Metro)
10 - Luciano Orquera (Brive)
9 - Pablo Canavosio (Aironi)
1 - Salvatore Perugini (Aironi)
2 - Leonardo Ghiraldini (Benneton Treviso)
3 - Martin Castrogiovanni (Leicester Tigers)
4 - Carlo Del Fava (Aironi)
5 - Quintin Geldenhuys (Aironi)
6 - Valerio Bernabo (Benneton Treviso)
7 - Alessandro Zanni (Benneton Treviso)
8 - Sergio Parisse (Stade Français)(captain)
16 - Fabio Ongaro (Aironi)
17 - Andrea Lo Cicero (Racing Metro)
18 - Santiago Dellape (Racing Metro
19 - Robert Barbieri (Benneton Treviso)
20 - Fabio Semenzato (Benneton Treviso)
21 - Kris Burton (Benneton Treviso)
22 - Gonzalo Garcia (Benneton Treviso)