Wales women's head coach Jason Lewis has made five changes to his side to face the flying Scots Women.
Scotland overcame France 10-8 in a tense encounter last weekend and will head south full of confidence.
On the other hand, Wales were heavily beaten 31-0 by England in the opening round of fixtures but Lewis believes his charges can get their campaign back on track against Scotland at Bridgend on Sunday.
Centre Clare Flowers has been forced out with a shoulder injury and is replaced in the midfield by skipper Mellissa Berry.
Local Bridgend girl Laura Prosser replaces Amy Day at scrum-half, Becky Newton comes in at hooker with Jenny Davies shifting to tighthead prop, Rachael Davies replaces Berry at No.8 while Claire Donavon slots in at lock.
Lewis said: “We were disappointed with the score against England but pleased with elements of our performance.
“We will be looking to kick start our Six Nations campaign with a good performance and a good result this weekend.
"Scotland will be full of confidence after their 10-8 victory over France last weekend and will be looking for another scalp so we will have to be on our toes to meet the challenge.
"With Clare Flowers out injured we opted to switch Mel Berry to the centre rather than re-jigging the backline.
“Mel has the skills and ability to play at centre and we are blessed with options at lock and back row.
“It's a great opportunity for Becky Newton to start at hooker and good to see Rhian Bowden back on the bench after injury.
“We are still looking at various combinations and we hope that a good home crowd will give us an extra boost on Sunday."
Non Evans (Cardiff Quins); Aimee Young (UWIC), Ceri Redman (UWIC), Mellissa Berry (Blaydon (captain), Caryl James (Cardiff Quins); Awen Thomas (Unattached), Laura Prosser (Cardiff Quins); Catrin Edwards (Cardiff Quins), Becky Newton (Cardiff Quins), Jenny Davies (Waterloo), Gemma Hallett (Pontyclun), Claire Donovan (Saracens), Catrina Nicholas (Cardiff Quins), Jamie Kift (Bristol Ladies), Rachel Taylor (Cardiff Quins)
Rhian Bowden (UWIC), Claire Horgan (Saracens), Louise Horgan (Saracens), Lisa Newton (UWIC) Amy Day (Bristol Ladies), Elinor Snowsill (Loughborough), Mared Evans (UWIC)