The Official Online RBS 6 Nations Store is open. The store has everything you need to get behind your team during the RBS 6 Nations, plus the store is now fully stocked with a much wider range of rugby merchandise.
Earls touched down in either half while Denis Hurley, O'Callaghan, Paul Warwick and Donnacha Ryan also scored, while O'Gara added 12 points in an emphatic victory.
Alessandro Zanni grabbed an interception score but the Italian champions never looked likely to trouble Munster.
Meanwhile, Leinster secured a bonus-point victory over French club Brive to move clear at the top of Heineken Cup Pool Six.
The reigning Heineken Cup champions were awarded a penalty try on 26 minutes, with Sexton adding the conversion, while Isa Nacewa, Gordon D'Arcy and Brian O'Driscoll scored second-half tries for Leinster.