Munster's British and Irish Lions Paul O'Connell, Donncha O'Callaghan, Keith Earls and Ronan O'Gara are set to feature for the first time this season in the Magners League clash at home to Newport Gwent Dragons on Sunday.
South Africa centre Jean de Villiers, who faced the Lions this summer, could make his Munster debut after being named in a 25-man squad.
David Wallace and Jerry Flannery, the two other players besides John Hayes who made the initial Lions party, remain on the injured list.
Peter Stringer (calf strain) and Paul Warwick (foot ligament) are also missing, while Doug Howlett gets a rest having played in three consecutive games.