Ireland internationals Leo Cullen, Shane Horgan, Bernard Jackman and Jonathan Sexton come into Leinster's starting line-up to face London Irish tomorrow evening at Donnybrook.
Sexton will partner Simon Keogh at half-back for the clash with the Exiles, who have been drawn with Leinster in Pool 6 for this season's Heineken Cup.
Fergus McFadden will line alongside Shaun Berne at centre and Isa Nacewa reverts to the left wing after starting at centre in last week's 38-10 victory over Rugby Nice Côte d'Azur.
Sean O'Brien will start in the back row alongside Shane Jennings and number 8 Stephen Keogh, who captained the province in that Nice win.