England will give back row Chris Robshaw his Test debut as one of two changes for Saturday's second Test against Argentina in Salta.
Robshaw replaces James Haskell, who drops to the bench, in the number six jersey while Leicester veteran Julian White comes in for David Wilson.
Harlequins blindside Robshaw made his first senior appearance for England in the 33-26 defeat by the Barbarians on May 30 but was axed for the opening Test against Argentina.
White played just seven minutes of Saturday's 37-15 victory over the Pumas at Old Trafford - his 50th cap - after being sin-binned for foul play shortly after coming on as a second-half replacement.
Wilson, the Newcastle prop, must settle for a place among the substitutes where hooker George Chuter replaces Steve Thompson with Jordan Crane dropping out of the 22.
England manager Martin Johnson has opted against promoting Ben Kay to the starting line-up and the Leicester lock must spend another match on the bench.
Captain Steve Borthwick wins his 50th cap as England attempt to end their season with a fourth successive Test victory.
They replaced Argentina in fifth place in the IRB world rankings with last weekend's victory.