Rory Best will lead an Ireland team containing six uncapped players for the opening game of the summer tour against Canada in Vancouver on Saturday.
Tom Court will make his first start for the Irish at loosehead, accompanied by Tony Buckley at tighthead in a front row built around Best’s experience.
Bob Casey’s last cap came nine years ago, also against Canada, but he starts in the second row with Mick O’Driscoll.
Denis Leamy will win his first cap at number eight and will be joined on the flank by debutants John Muldoon and openside Niall Ronan.
The backline contains four new caps, including Ian Keatley who will partner Ireland’s most-capped scrum-half Peter Stringer, while Munster supply the wingers in Barry Murphy, on the right, and debutant Ian Dowling on the left. Gavin Duffy will complete the back three.
Ulster duo Darren Cave and Ian Whitten are the other two players who will earn their first cap at the weekend.
G Duffy (Connacht), B Murphy (Munster), D Cave (Ulster), I Whitten (Ulster), I Dowling (Munster), I Keatley (Connacht), P Stringer (Munster), T Court (Ulster), R Best (Ulster), T Buckley (Munster), B Casey (London Irish), M O'Driscoll (Munster), J Muldoon (Connacht), N Ronan (Munster), D Leamy (Munster).
Sean Cronin (Connacht), M Ross (Harlequins), R Caldwell (Ulster), D Ryan (Munster), E Reddan (London Wasps), N O'Connor (Ulster), D Hurley (Munster)