Canada coach Kieran Crowley has named Glasgow Warriors prop Kevin Tkachuk and Bedford Blues full-back James Pritchard in his XV to face Ireland at Thomond Park on Saturday.
Tkacuck, capped 40 times in the front row, features in a team captained by hooker Pat Riordan, as the Canucks seek a first victory over their opponents.
"It is a big test of this team - that is why they are called Tests - and we have to see if the systems we are putting in place will stand up to what Ireland has to offer," said Crowley.
Crowley’s side warmed up for the clash with a 21-13 win over Portugal on Saturday.
Three National Division One players also make the team - Bedford's Pritchard, scrum-half Ed Fairhurst, of Cornish Pirates, and Plymouth Albion flanker Sean Michael Stephen.
Fly-half Matt Evans, who plays for Hartpury College in Gloucester, could make his international debut from the bench.