Cipriani’s inclusion is one of three changes made by manager Martin Johnson, with Bath pair Michael Lipman and Nick Abendanon replacing Leicester’s Lewis Moody and Tom Varndell.

Cipriani, 20, was left out of Johnson’s original 32-man squad because he was not expected to recover from a fractured dislocation of the ankle in time.

But the Wasps star returned to action on October 1, six weeks ahead of schedule and just 24 hours after Wilkinson suffered a dislocated right knee cap.

Lipman replaces Moody, who is recovering from surgery on his left hip and left Achilles tendon.

Johnson said: “Danny Cipriani has made a good recovery from his injury and returned earlier than expected.

“He’s performed well since he came back and, while there was strong competition from other players, I have decided to give Danny the chance to compete for a place in the 22 for the Pacific Islanders match on November 8.

“Michael Lipman was very unlucky not to make the original 32-man Senior EPS squad and he has been playing very well for his club this season.

“The England medical team and I will continue to liaise closely with Jonny and Lewis and their clubs and I wish both of them a speedy recovery. Lewis is getting closer to playing for Leicester Tigers and I look forward to seeing him back in action soon.

“I’m disappointed for Tom Varndell but he has not been selected by Leicester recently and we will monitor his form when he starts playing regularly again and competing for a place in the squad.”

England face the Pacific Islands at Twickenham on November 8 before Tests against Australia, South Africa and New Zealand.